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DNA Connections
It may be possible to confirm family relationships with Thomas by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Thomas:
Is it possible that Thomas Jefferson Anderson is the son of Thomas Nicholas Anderson and Mary Elizabeth Garberson Anderson? They had a son by that names, born in the mid 1850s (the family record says "I believe it was 1855" so may not be 100% accurate.