In the 1880 Hopkins County, Kentucky census entry for her daughter, Jane Crabtree Ashby, her mother's place of birth is recorded as Tennessee.
Sources
1820 U S Census; Census Place: Hopkins, Kentucky; Page: 238; NARA Roll: M33_23; Image: 140. 1820 United States Federal Census. Provo, UT, USA: Ancestry.com Operations, Inc., 2010.
Ancestry.com. OneWorldTree. Provo, UT, USA: The Generations Network, Inc.
Hopkins Co. KY Order Book 1840-1846, pg 205, August 1884.
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DNA Connections
It may be possible to confirm family relationships with Isabell by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isabell: