It is likely that Margaret died in 1819 because there is a record in the kirk session of Mortlach for a coffin being purchased for 7 shillings for Margaret Duff.
Sources
Parish record of her birth/baptism in 1800 in Mortlach - obtained from scotlandspeople.gov.uk
"The Book of the Duffs" compiled by Alistair and Henrietta Tayler and published in 1914.
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: