Margaret, who was named after her mother, was John W. Heller's twin. She died unmarried at age fifty.
Sources
Commemorative Biographical Record of Northeastern Pennsylvania: Including the Counties of Susquehanna, Wayne, Pike and Monroe, Containing Biographical Sketches of Prominent and Representative Citizens, and Many of the Early Settled Families, J.H. Beers & Co., Chicago, 1900, p. 269.
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: