Margaret might be the Margaret Adams who died in Dauphin, PA in 1923; need to check Ancestry.
Sources
"United States Census, 1900," index and images, FamilySearch (https://familysearch.org/pal:/MM9.1.1/MS1C-PS1 : accessed 20 Jan 2014), Margaret S Houck in household of Charles E. Houck, Butler Township, Adams, Pennsylvania, United States; citing sheet , family 141, NARA microfilm publication T623, FHL microfilm 1241354.
"United States Census, 1910," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MGD9-DY5 : accessed 22 January 2023), Margaret L Houck in household of Charles E Houck, Biglerville, Adams, Pennsylvania, United States; citing enumeration district (ED) ED 2, sheet 17B, family 373, NARA microfilm publication T624 (Washington D.C.: National Archives and Records Administration, 1982), roll 1292; FHL microfilm 1,375,305.
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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: