The Barnstable Vital Records show that John was born on August 25, 1681, to John Issum and Jane Parker, He married Deborah Daggett in 1717 in Massachusetts. He died in 1773 in Connecticutt.
Sources
A survey of the Ishams in England and America : eight hundred and fifty years of history and genealogy, p 117
American Genealogical-Biographical Index (AGBI)
Colonial Families of the USA, 1607-1775, p 248
Global, Find a Grave Index for Burials at Sea and other Select Burial Locations, 1300s-Current
International Genealogical Index. The Church of Jesus Christ of Latter-day Saints, Family Search IGI Publication: www.familysearch.org Copyright (c) 1980, 2002
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DNA Connections
It may be possible to confirm family relationships with John by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: