It appears that Lena and William Klapmeyer divorced between 1920 and 1930 as the 1930 US Census showed William Klapmeyer as divorced. I didn't find Lena in the 1930 US Census. Lena reappears in the 1940 US Census married to Virgil Clifford Akers, The Missouri Marriage Records show Lena and Virgil getting married in December of 1943. Then Lena and Virgil appear to have divorced as Lena and William Klapmeyer remarry in August 1949 according to the Missouri Marriage Records. I checked the birth dates and everything seems to check out. I haven't been able to find any divorce records.
Sources
*1900 US Census
1910 US Census
1920 US Census
1940 US Census
Kansas State Census Collection, 1855-1925
Missouri, Marriage Records, 1805-2002 (1905 Marriage to William H. Klapmeyer)
Missouri, Marriage Records, 1805-2002 (1943 Marriage to Virgil Akers)
Missouri, Marriage Records, 1805-2002 (1949 Marriage to William H. Klapmeyer
US, City Directories, 1822-1995
US, Social Security Death Index, 1935-2014
US, Find A Grave Index, 1600s - Current
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DNA Connections
It may be possible to confirm family relationships with Lena by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Lena: