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DNA Connections
It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret:
"Pennsylvania, Church Marriages, 1682-1976," database with images, FamilySearch (https://familysearch.org/pal:/MM9.1.1/Q2WF-P6YT : accessed 2 August 2018), Owen Owen and Katherine Lewis, 24 Oct 1722; citing Christ Church Philadelphia, Philadelphia, Pennsylvania, United States, various churches and archives, Pennsylvania; FHL microfilm 823,996.
Her parents were:
"Pennsylvania, Church Marriages, 1682-1976," database with images, FamilySearch (https://familysearch.org/pal:/MM9.1.1/Q2WF-P6YT : accessed 2 August 2018), Owen Owen and Katherine Lewis, 24 Oct 1722; citing Christ Church Philadelphia, Philadelphia, Pennsylvania, United States, various churches and archives, Pennsylvania; FHL microfilm 823,996.