Isaac Lincoln was a son of "Virginia John" Lincoln, so named in "Virginia John's" 1786 will, transcribed by Waldo Lincoln in a book published in 1923. As such, Isaac was bequeathed two shillings six pence.
Sources
Lincoln, Waldo, A.B., "History of the Lincoln Family. An Account of the Descendants of Samuel Lincoln of Hingham Massachusetts 1637-1920", Worcester, MA (1923), pp. 94-96 at [1].
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isaac: