Found United States Federal census information on several families with Florence and Margaret as the parents. Two in NYC, one in Vermont, two in upstate New York. But none really panned out. Where did Florence and Margaret raise their kids? If they were in the USA, there would many good records to review. But, it is in Ireland where there are gaps in the records and where the records are missing or destroyed. Best guess is that when Florence died, the younger and unmarried kids all left Ireland. Another guess is that the five brothers waited for the US Civil War to get finished before they came to Massachusetts to work in the leather business.
Records
Baptism of Florence McCarthy of Killarney on 27 August 1797
Name Florence McCarthy (recorded as Florentium)
Date of Birth 27 August 1797 (Based on other date information)
↑
Tralee; County of Kerry, Diocese of Kerry, Baptisms, Apr 1818 to Jan 1819; Microfilm 04270/05 | page 118
Name was mentioned in the marriage records of two children (John & Jeremiah) and the death records of six children (Mary, John, Timothy, Thomas, Jeremiah, & Dennis)
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DNA Connections
It may be possible to confirm family relationships with Florence by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree:
Jim McCarthy :
Family Tree DNA Y-DNA Test 111 markers, haplogroup R-A9070, Ancestry member jimac015, FTDNA kit #B23719 +
Y-Chromosome Test
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Florence: