The Doane Family Deacon John Doane of Plymouth and Doctor John Doane of Maryland and Their Descendants Fourth Edition 1984 by Alfred Adler Doane Page 191
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DNA Connections
It may be possible to confirm family relationships with Holmes by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: