He was married about 1717 to Mary Mansfield, and they had 5 children.
Sources
"Pedigree Resource File," database, FamilySearch (https://familysearch.org/ark:/61903/2:2:3DJS-STR : accessed 1 March 2018), entry for James /Searl/; "Huber/Jenkins Family Tree" file (2:2:2:MM6M-581), submitted 8 April 2017 by William E Huber [identity withheld for privacy].
Anderson, Robert Charles, et al., The Ancestry of the Royally-Descended Mansfields of The Massachusetts Bay, NEHGR (NEHGS, Boston, Mass., 2001) Vol. 155, Page 35.
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DNA Connections
It may be possible to confirm family relationships with James by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree:
There's a James Searls, born 12 Feb 1675 in Northampton, Hampshire, Mass. in Find A Grave. The double dating explains the year difference, however there is also a difference for month of death. His gravestone and the information in the memorial say he died 05 November 1728 (not May) in Northampton. His memorial ID is 14432183. I think this is the same person.
I have been trying to determine if James Searls and his wife Mary Mansfield are the parents of my ancestor Isaac Salls/Searls (1723-1800). My Isaac had connections to Salisbury Connecticut, Long Island, Livingston NY (Canaan), and Clarenceville, Missisquoi, Quebec, Canada. I do not have evidence that he ever lived in Northampton, Mass. and I also do not have any records of him in his childhood. If anyone is able to help me with this, let me know!
I have been trying to determine if James Searls and his wife Mary Mansfield are the parents of my ancestor Isaac Salls/Searls (1723-1800). My Isaac had connections to Salisbury Connecticut, Long Island, Livingston NY (Canaan), and Clarenceville, Missisquoi, Quebec, Canada. I do not have evidence that he ever lived in Northampton, Mass. and I also do not have any records of him in his childhood. If anyone is able to help me with this, let me know!