Catherine was born circa 1745. She was not yet married when her father wrote his will on 2 January 1768, but was married by the time her mother wrote her will on 14 July 1775.
Sources
"Maryland Register of Wills Records, 1629-1999", digital image, FamilySearch (Online: Intellectual Reserve, Inc., 2020), [Original source: St. Mary's County Orphans Court, "Will of Thomas Spalding", Will Book TA1, pp. 581-582]
"Maryland Register of Wills Records, 1629-1999", digital image, FamilySearch (Online: Intellectual Reserve, Inc., 2020), [Original source: St. Mary's County Orphans Court, "Will of Catherine Spalding", Will Book TA1, pp. 723-724]
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DNA Connections
It may be possible to confirm family relationships with Catherine by comparing test results with other carriers of her ancestors' mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Catherine: