This book states she died in Massachusetts, but I do not think this is right. I found a gravestone for her & her husband Henry B. Kelsey in LaPorte Cemetery in Lorain County, Ohio.
Sources
The Carr Family Records by Edison Irving Carr, pages 211-212, published 1894
"United States Census, 1850," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/1:1:MXQ2-3NL : 21 December 2020), Roena S Kelsey in household of Henry B Kelsey, Carlisle, Lorain, Ohio, United States; citing family , NARA microfilm publication (Washington, D.C.: National Archives and Records Administration, n.d.).
Find a Grave, database and images (https://www.findagrave.com/memorial/12683728/rowena-kelsey: accessed 14 July 2023), memorial page for Rowena Sweet Kelsey (27 Aug 1814–19 Dec 1883), Find a Grave Memorial ID 12683728, citing Laporte Cemetery, Grafton, Lorain County, Ohio, USA; Maintained by Joyce (contributor 831).
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DNA Connections
It may be possible to confirm family relationships with Rowena by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Rowena: