Husband, Emanual, appears to have gone by "Manual". Daughter Harriet Grace appears on the 1850 census along with Manual and Mary. On the marriage record, husband's name is given as "Amanuel".
Both the Massachusetts death record and Find A Grave give death year as 1881 (November 11), rather than 1891.
Sources
"Maine Marriages, 1771-1907," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:F4FJ-FQ6 : 10 February 2018), Amanuel Grace and Mary Tuttle, 13 Oct 1822; citing Lovell,Oxford,Maine, reference ; FHL microfilm 11,541.
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MWZL-1PH : 12 April 2016), Mary Grace in household of Manuel Grace, Strafford, Strafford, New Hampshire, United States; citing family 1041, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
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DNA Connections
It may be possible to confirm family relationships with Mary by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Mary: