In 1804 my 4x great-grandfather, Capt. Edward Worthington, left his home at Worthington Station, Kentucky, to travel on business to New Orleans. Once there, he contracted yellow fever and died. We have no idea where he was buried.
Then, in June of 1919, my grandfather, J.P. Griggs, was running the Rondale Hotel in Adrmore, Oklahoma. He became ill and a doctor sat up with him all night, but left in the morning for find himself some breakfast. When he returned, Joe had succumbed to the disease and died from "natural causes." I always thought it was probably the Spanish flu, but can't prove it as OK didn't keep death records then.