You are going to have fun with this one. Did a little research on ancestry.com. Mary Alice "Little Granny" Sizemore has quite a history, some fiction (probably), some not. She had four sons, all different fathers: Shadrack Hall (b ca 1789), Isaac Stevens (b ca 1790), Isom (Isham) Adkins (b ca 1795), Hiram Slone (b ca 1797). According to one story she was only legally married to Hiram's father, William Hiram Slone. He reportedly adopted the other boys, which is why they have the Slone name. She was not married to Isom (Isham) Adkins, he was her son. Mary's husband Wm Hiram Slone died before 1810.
Some say she was not a Sizemore. Some say she was part Creek Indian. Some say she was mulatto, Indian & white. Or the first white woman to settle in Kentucky. Take your choice.
Kentucky death records: Isham Slone died of consumption 15 Apr 1855 in Floyd Co., KY, age 60, parents not known.
Kentucky marriages: Isham Slone md Polly Reynolds, 26 Oct 1815, Floyd Co., KY.
Mary Slone is on census:
1810, Flyod Co., KY, 1 male under 10, 1 male 10-15
1820, Lee Co., VA, 1 male 10-15, 2 females 10-15, 2 female 16-25, Mary 45 + (no idea who the females are. Mary is said not to have had any daughters.
1830, Lee Co., VA, 1 male 20-29, 1 female 20-29, Mary 60-69; may be son Hiram and wife; Mary was living with them in 1850
1840, Lee Co., VA, 1 female 15-19, Mary 70-79
1850, Floyd Co., KY, Mary Slone, age 100 (should be ca 85), Hiram Slone, age 53, Temperance Slone, age 50 and several children.
I wish you luck.
Edit: one more census record just to confuse things.
1810, Floyd Co., KY, Isham Adkins, age 26-44, 2 males under 10, 1 male 16-25, 1 female 26-44