Yes and I think people don't tend to realize just how few people actually lived in America around that time. These people made more people and so on - literally tens of millions of descendants today. Esp if you had ancestry in that New England area around that time, you might actually have a high probability of being a descendant of these folks. Still, as commonplace as that ancestry is, the history is interesting if you get into it.
There are definitely many Mayflower-descendant profiles in need of development as well. You'd think after 500 years, descendants would already be fairly well documented for a few generations down. Possibly elsewhere, or in private trees, but not so much yet on wikitree.