My own preference is to contact the Profile Manager first before making changes. You can put a message on the profile page. It will automatically get emailed to the profile manager; or you can send a private message to the profile manager. To do that, click on the link for the profile manager on the profile's page, then you will find a link to send the profile manager a "private message."
If the profile does not have a profile manager (displays as orphan), you can adopt it and become the Manager.
If there is no response, that is another issue and there is a procedure for that under the help menu (unresponsive manager).