Fifty people, Jillaine? Wow.
Joe, are you asking if it works if you have already imported a GEDCOM? It won't work on past uploads, but this is what FindMatches is for. GEDMatches is essentially just an extension of FindMatches to work on GEDCOMs before they're imported.
Also, we added MatchBot to do some of the FindMatches work in the background, so you wouldn't have to keep re-running it.