The profile for John Harrod Sr. (Harrod-218) seems to follow most online genealogies (example) with the following exceptions/notes:
1. First wife Caroline Downey is sometimes given instead as Mary Ellis.
2. John Jr. is sometimes attributed as the eldest child of the second wife Sarah Moore, and not of the first wife
3. John Sr. is attributed other children, not yet reflected on Wikitree: Eleanor, Sally, Elizabeth, and Jemima. Wikitree has one child that I did not see listed elsewhere: Isaac (Harrod-226)
John Sr.'s eldest son, Thomas (Harrod-219), is given in another online genealogy as marrying both Mary Noel and Hannah Ellsworth. with children given as Isiah, James, Jane, Elizabeth, Leah, Lucinda, Rachel, Susannah, Hannah, John, Samuel, Mary (AKA "Polly"), and Jesiah.
Based on this I would say that Harrod-219 and Harrod-56 may represent the same person - but again this is simply based on other online genealogies and not actual sources.
To answer the original question Harrod-225 and Harrod-58 *may* be related as uncle/nephew who are coincidentally born near the same year, I think it is pretty clear however that they are not the same person, and that the claim of being founder of HarrodsBurg belongs to Harrod-225 not Harrod-58. My reasoning is that I would assume the Old Fort Harrod state park would probably have done fairly intesive research on their founder, and probably had a hand in writing the description for the state parks website.(link)
You may also find this blog of some use for Harrod information - the author cites a wide variety of sources and often highlights the inconsistencies between accounts.