I found some information for you that may be helpful. According to Census records, marriage, and other MEADOWS researchers:
LITTLETON TOLBERT MEADOWS was born June 15, 1818 in Coffee Co., TN and died Aug. 11, 1879 in Coffee Co., TN.
He married first ELIZABETH RAYBURN, who was born about 1812 in Virginia. The children by his first wife are; NANCY, SARAH, PERMIELIA, MARY, JAMES, MARTHA and HARRIETT MEADOWS.
LITTLETON MEADOWS is found on the 1840 Coffee Co., TN Census - there are 3 white members and 1 slave in the household - total of 4 persons.
LITTLETON MEADOWS is found on the 1850 District 2, Coffee Co., TN Census - and the 1850 Slave Schedule states that he owns one slave - a 43 year old black female. Information on the 1850 Census is transcribed below:
Head of household, LITTLETON MEADOWS, age 32, born in Alabama, estate is worth $500, he is a farmer.
Wife, ELIZABETH MEADOWS, age 38, born in Virginia.
NANCY, age 9, born in TN.
SARAH, age 7, born in TN.
PERMELIA, age 6, born in TN.
MARY, age 4, born in TN.
JAMES, age 1, born in TN.
If you will look at the original 1850 Census, you will see that the "birth place" of LITTLETON is a "ditto" mark - the individuals listed above him were born in Alabama. I think the Census taker made a small error.
LITTLETON MEADOWS married his 2nd wife, MARTHA ANDERSON CASS on Oct. 28, 1858 in Coffee Co., TN. Perhaps his first wife, ELIZABETH, has died.
MARTHA ANDERSON CASS was born July 6, 1834 in Coffee Co., and died Sept. 23, 1879 in Temple, Bell Co., Texas. She was the daughter of MOSES MADISON CASS and LUCRETIA "LUCY" WEBSTER.
I found LITTLETON and his 2nd wife, MARTHA, on the 1860 District 2, Coffee Co., Tennessee Census:
Head of household, L MEADOWS, age 45, real estate is worth $500, personal estate is worth $1,000, he is a farmer. (NOTE: The column "place of birth" is left blank on this Census)
Wife, MARTHA MEADOWS, age 27.
SARAH, age 17.
PERMELIA, age 16,
MARY, age 14.
JAMES, age 12.
MARTHA, age 10,
HARRIETT, age 7.
WILLIAM, age 10 months.
NOTE: All of the children listed are ELIZABETH's except the youngest, WILLIAM, who is the first child of LITTLETON and MARTHA.
Well, that's about all I could find for now - some of it I found by typing in "Littleton Tolbert Meadows" in my search engine.
I hope this helps you in your search! Sincerely, Melinda