I'm sorry but I came up with a negative result . I've put in step by step what I checked to help in any future research . I would suggest that it would help to research her existence in Virginia!
I followed the one source on the profile,
http://wc.rootsweb.ancestry.com/cgi-bin/igm.cgi?op=GET&db=bfurr1&id=I47918
The tree gives no details on the marriage but suggests that William came from Durham.
I searched on Ancestry UK and got no results for a marriage between a William Blackstone and a Sarah Boylston in any record.
There were several trees with the marriage so I looked at them . Many had a date and place for this marriage, 9th Nov. 1626 at All Saints Newcastle upon Tyne. The only source I found was other ancestry trees.
I then looked to see if there was any good coverage of this parish
https://familysearch.org/wiki/en/All_Saints,_Newcastle_upon_Tyne,_Northumberland_Genealogy#Parish_Records
( This is usually a very useful search as it lists all the other places other than family search that have records for each parish. For this pairsh though it suggests that no-one has the images of the registers or full transcriptons so to check fully you would have to visit the archives)
However, the IGI did index the registers
I used Hugh Archer's useful site which makes it easy to search just the one batch of indexes http://www.archersoftware.co.uk/igi/fs-nbl.htm#N
I searched batch number MOO4291 (marriages All Saints, Newcastle 1600-1812 for Blackstone
Here's the result
Name John Blakstone Spouse's Name Suzan Chamber
Event Date 09 Nov 1626 Event Place All Saints,Newcastle Upon Tyne,Northumberland,England
"England Marriages, 1538–1973 ," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:N27D-KBM : 10 December 2014), John Blakstone and Suzan Chamber, 09 Nov 1626; citing All Saints,Newcastle Upon Tyne,Northumberland,England, reference ; FHL microfilm 95,005, 95,006, 95,007, 95,009
Right date according to all those trees, right grooms surname but everything else incorrect. (and it appears that this is actually the marriage of John Blakiston the regicide, https://en.wikipedia.org/wiki/John_Blakiston )
Edit went back to all those trees on Ancestry; some had the marriage taking place on the same date in Virginia, some had the marriage taking place in Virginia at anything from 1625-1698, no sources (and a couple had him marrying Susan Chambers first) I note that the findagrave entry says his wife is unknown (also unknown birth location within England)
