From what I've gathered, It was almost certainly taken in Stanton, Nebraska.
In the 1900 census we find one M.H. Stocker, who is listed as a druggist.
"United States Census, 1900," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M313-NWZ : accessed 6 September 2017), M H Stocker, Stanton Precinct Stanton city Ward 1-2, Stanton, Nebraska, United States; citing enumeration district (ED) 178, sheet 7B, family 158, NARA microfilm publication T623 (Washington, D.C.: National Archives and Records Administration, 1972.); FHL microfilm 1,240,941.
In the same town is a W.H. Person, who in 1900 is listed as a physician
"United States Census, 1900," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M313-K1D : accessed 6 September 2017), W H Person, Stanton Precinct Stanton city Ward 1-2, Stanton, Nebraska, United States; citing enumeration district (ED) 178, sheet 8B, family 177, NARA microfilm publication T623 (Washington, D.C.: National Archives and Records Administration, 1972.); FHL microfilm 1,240,941.
I can imagine a druggist and physician working together. Not to mention that also in Stanton is W.M Beutel. In 1900 he's listed as a painter, but it's possible he operated a saloon for a time.
"United States Census, 1900," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M313-2ZV : accessed 6 September 2017), Wm Beutel, Stanton Precinct Stanton city Ward 1-2, Stanton, Nebraska, United States; citing enumeration district (ED) 178, sheet 4A, family 71, NARA microfilm publication T623 (Washington, D.C.: National Archives and Records Administration, 1972.); FHL microfilm 1,240,941.
if you look above the saloon, you can see in the window "earney, Lawyer" While the first letter of the name cannot be seen, I took a wild guess and tried Kearney.
Sure enough. Living in 1900 in Stanton. A.A. Kearney. Lawyer"
"United States Census, 1900," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M31Q-SQB : accessed 6 September 2017), A A Kearney, Stanton Precinct Stanton city Ward 1-2, Stanton, Nebraska, United States; citing enumeration district (ED) 178, sheet 2B, family 34, NARA microfilm publication T623 (Washington, D.C.: National Archives and Records Administration, 1972.); FHL microfilm 1,240,941.
So, all the names I can find in the picture, appear in the year 1900, living in Stanton Nebraska. And all but one have the right profession.
I looked in the street view for Stanton and there's only one or two intersections that could have been taken. But none of the buildings can be recognized. But it's more than possible that all the buildings pictured, are no longer standing.
I hope this helps.