Hello Tammy. My grandmother was a Caldwell from the WV clan. Some of our ancestors migrated to Harlan County Kentucky, so perhaps others from our family moved on to TN.
If you don't have info on John Acey Caldwell's parents, there is an Ancestry.com tree belonging to paul_scott_stanford that lists them as James Caldwell 1800 - 1848 born in Virginia and married to Rebecca Cleary. And an 1850 census with Rebecca and children, including John aged 22 in District 10, Fayette, Tennessee.
I don't see a link yet between James b 1800 in Virginia and my Caldwell's, but very likely that there is one.