If she is the Hanora Simas who died and was buried in El Dorado county, she is listed in the California death index, thus her death certificate should be available. She is on Find-a-grave, as is one of her sons (John) and his children. There is a Simas family plot in the Latrobe, California Cemetery.
Her husband is not there.
I did not find them in the 1870 or 1880 census. There are several Manuel Simas’s, but none in a family with Hanora.
I wonder if they separated, or divorced, or possibly Manuel dies early.
Perhaps trying to find any mention of the family in a local newspaper would be helpful; perhaps there is an obituary.