Gail, in the 1850 census for Wayne County, Ohio, Jame and his wife Christina were living next door to (possibly) a couple of brothers. Two households down from James is a William Lilly, age 29. In William’s household is a Mary Lilly, at 57. It’s possible that James’ father was already dead, and that his older brother was caring for the mother, Mary.
That’s all I can dig up at the moment. If I find something new, I’ll be sure to post it for you.