Can I a join a DNA project maybe of Genealogy may help me with?

+3 votes
116 views
Hi Genealogys Im missing a piece of my DNA a small piece of 22 Chrosome or something sorry for my spelling which is called 22q11.2 my cousin thinks it could have messed with my DNA on my father side on Ancestry DNA. I was just wondering if you can see if I has a Double Helix or something or a RNA DNA .  I am missing a small piece of 22q. it would be cool if you genealogy would be able to figure what small piece im missing or if I even have it .... my mother thinks I has 22q. but I dont think so idk?.  Soon I will be doing 23andMe later on the Health part maybe we will find answers but im unsure.  I think my cousin said I am and her are link to the royal blood line of king james which I dont know who king james is yet. I think Im link to Royal Queen Elizbaeth 2nd on my father side are you guys genealogy able to verify it.  this would be a great project for you guys to figure out of my DNA :) I think lol.  but not sure how you guys Genealogys will figure it out I has been tested on here I think?. :D good luck please email me at (redacted by moderator@gmail.com) if you guys figure out anything you can help me with of this project Im unsure who my father is also :(.
in Genealogy Help by CameoNicole Blewett G2G Crew (340 points)
retagged by Lynda Crackett
Hi Cameo,

I'm not sure if that's possible however if you want help finding your father it might help to contact the adoption angels. I don't know if you have been adopted but they may have some ideas they could pass to you.

You can contact them by clicking the help tab and than adoption_angels.

Best regards
I don't know about chromosomal anomalies, but I DO know that Queen Elizabeth II is a descendant of King James (12 generations later).

King James ruled 1603-1625. His monarchy was important, because when he ascended the throne he already happened to be King of Scotland. The two countries were ultimately combined peacefully that way.

James was the beginning of the Stuart dynasty through James' son, Charles I. But when that dynasty came to an end, a grandson of Charles' sister, Elizabeth (who was never queen) took over. That was George I, the start of the Hanover dynasty. The previous monarch, Queen Anne, was his second cousin.

Since George I, succession has been more straightforward. George II passed the throne to a grandson, George III, who passed it to his son, George IV. Then it went to IV's brother, then IV's niece, Queen Victoria. The next five generations have all gone from parent to child, leaving us at Queen Elizabeth. For some reason, her gt-grandfather is considered the start of the Windsor dynasty.

1 Answer

+7 votes

CameoNicole, The best way to find out if you have any royal connections is to start building your branches of the tree using the paper trail you can find. You can later confirm that using your DNA matches. I doubt if you will make much progress looking for pieces of DNA that you think you are missing or trying to find people who can help you to look for them. Wikitreers are very helpful people, but you are unlikely to find anyone who is going to do all of the work for you, and I doubt if you will find many genealogists who would know how to tackle your question about 22q, especially if it is a health related issue. My recommendation would be:

  1. Document what parts of the tree that you can from the paper trail by adding sourced profiles to your branches of the tree
  2. Use your DNA matches at AncestryDNA to find evidence that supports or disproves that paper trail.
  3. Transfer you Ancestry results to other sites such as FTDNA, MyHeritage, LivingDNA and gedmatch so that you will get a broader pool of matches to work with.
  4. When you take the 23andme test use the genealogy results as well as the health reports.
by Lynda Crackett G2G6 Pilot (622k points)

CameoNicole, I'll echo Lydna's (always) good advice, and add just a couple of items.

First, today's autosomal DNA tests--the kind AncestryDNA, 23andMe, MyHeritage, and Living DNA perform--can't tell us anything at all about biological connections to King James (IV of Scotland and I of England) or any of the early Stuarts. In fact, due to the way our DNA scrambles and then mingles every time a child is born, autosomal DNA matching with living test-takers is almost impossible to use with any accuracy beyond 5th cousins (4g-grandparents). If ancient remains have been fully sequenced for comparison (which may be likely to happen with notables more often as time goes on because the technology has improved so much), we might be able to make useful correlations out as far 10g-grandparents. But that's about the extent to which autosomal DNA can go from the perspective of genealogy...and by that I mean family studies, who's related to whom; not population genetics or anthropology that tries to look way back into the past.

Second, whoever mentioned 22q11.2 to you has at least some level of understanding of this stuff. Chromosome 22 is our smallest, but there are a number medical conditions associated with deletions of tiny sections of it. There is an actual 22q11.2 Deletion Syndrome, which used to be called DiGeorge Syndrome.

But it is a medical condition, and DNA testing for genealogy will tell you nothing about it, or whether you might have it. Even 23andMe expressly states that its extended, or health testing results will provide no information about it. Largely, this has to do with the testing methods used: they just don't look at chromosome 22 with enough detail to provide any medical data. Bottom line: if you need or want information pertaining to a possible 22q11 deletion, you'll need to consult a medical professional.

That said, and with the understanding that I am not a medical professional and nothing I say can be considered medical advice... While 22q11.2 Deletion Syndrome can be hereditary, it seems to be passed down genetically only about 10% of the time. The deletion seems to occur most often as a random thing during gamete development (the mother's egg or the father's sperm) or during the rapid cell replication that happens during very early development of the fetus.  But we don't know every detail about it yet. The area contains up to 40 individual genes, most of which have yet to be adequately defined as to purpose and function. So for anyone with 22q11.2 Deletion Syndrome (or similar) it can be passed down to children, but if someone has it there's a better than 80% chance that neither parent does.

And because there are as many as 40 genes in that region, 22q11.2 Deletion Syndrome doesn't have a single set of symptoms. Some people might have most of that chunk of Chr22 missing, while others might be missing a much smaller section. That's one reason it's difficult to diagnose. And while rare, some form of the symptom isn't exceedingly rare; the NIH estimates as many as one in 4,000 people have deletions in this area of Chr22. 

(Only for the DNA nerdists among us--do we need a special T-shirt or call-sign or something?--this region is very near the centromere on the long arm of Chr22. The "p" always designates the short arm of a chromosome, and "q" the long (here is an interesting history of that naming convention, but I always remember "p" for "petit"). Chr22 is one of our acrocentric chromosomes, so most of the action occurs on the long arm. Depending on the map build you're using, 22's centromere will be somewhere around 14.8Mbp. You can spot it quickly by clicking on Chr22 at NCBI's 1000 Genomes Browser. The 22q11.2 position begins, in GRCh38, at about 17.4Mbp. Had to look that up, of course, so figured I may as well include it for the all the folks who, like me, never got out of the childhood habit of asking, "But, why?")  smiley

That one deserved to be an answer on its own rather than a comment under my answer Edison.

Nah. You answered; I just did my typical rambling thing. You wrote, "...who would know how to tackle your question about 22q..." and a little "ya know what?" lightbulb went off. Just so happened that I had a conversation a month or so ago about chromosome deletions, duplications, translocations, and inversions. Such an exciting luncheon raconteur. Ahem.

I made a mistake I want to correct before I get called on it. Chromosome 22 is not the smallest; Chr21 is...by 4,108,485 base pairs.  wink  Chr22 is the first autosome that was sequenced in the Human Genome Project, and one of the ones where the numbering got fouled up. The chromosomes were intended to be numbered from largest to smallest, but by that convention Chr21 should really be 22...and Chr10 and 11, and 19 and 20 should be swapped, too. But once they were named, they stayed that way.

Learn something new every day smiley

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