Yes Charles, it has been a few years since you uploaded that gedcom file. Things have changed since then and the new gedcom utility is called GEDCOMpare. A bit different than the old version. Please take a look at this page to familiarize yourself with the new GEDCOMpare.
GEDCOMpare Usage Primer
It still needs a little work, but gives you the basics. As you would be Editing existing Profiles, I would pay close attention to the pages listed there regarding GEDCOMpare Biography Clean up, Editing and Sourcing so you can get a great Profile right off the bat.
And Ellen is right that smaller gedcom files work better for the user. Easier to manage and maintain a sense of direction when working on it.
And Robynne is correct as well in many cases. If you want to make additions to 10 to 20 of your Profiles, I would rather cut and paste. But if you are talking 50 or more, I would look into a GEDCOM file upload.
The nice thing here is if you're using a GEDCOM file to only make Edits to existing Profiles and not creating new Profiles from new names in the list, you don't have to Confirm or Reject any Suggested Matches for those you don't care to work on. Just go to the names you want and Confirm your file name to your existing Profile and Edit it to import the new data. When done with all the names you want to work on, you can delete that GEDCOM file or within 60 days the system will automatically delete it. No muss, no fuss.
If however, you plan on adding new names to create new Profiles, you will definitely need to read the Primer I supplied above.
I just lost power and am on battery back up. Gotta go. Good luck.