Ok so there's a gentlemen that has been doing the DNA research for the past few years, but he doesn't have a large online presence.
Short Answer-
Descendants of James McDaniel that have taken a YDNA test have the R-M222 haplogroup/genetic marker which is gaelic instead of norse (which those descending from the Lords of Clan Donald are of norse descent). Descendants of Lt. Brian McDOnald and his son Bryan Jr. are in the R-S951/R-Z3000 haplogroup. SO there's a hick-up in the alleged lineage of Lt. Brian, as they also do not descend from the Lords of Clan McDonald. (http://www.peterspioneers.com/colla.htm). James Sr. of Maryland is actually related to the O’Flaherty clan and descends from the Uí Briúin, descendants of Conn Cétchathach of Connacht, Ireland.
For the distinction between the profiles- The birth date that is often used for both profiles belongs to the Delaware James (who married Catherine Justis). He is noted in the same church and in documents involving his father and other relatives in Delaware before he moved to Virginia (following his father).
New Castle, Delaware, Deeds, Book Q, Pg. 221, 494, 497-98
Archivum Americanum-Swedish Churches on the Delaware, Pg. 26
Here's another example of a source, showing he was at the same church as Bryan Jr.- "Delaware Births and Christenings, 1710-1896," database, <i>FamilySearch</i> (https://familysearch.org/ark:/61903/1:1:F7HD-QX1 : 10 February 2018), James Mc Donald in entry for Rebecca Mc Donald, 21 Mar 1752; citing ; FHL microfilm 908,217.
Regarding James- I see that the profile was raided. Thank you for those who are trying to restore it. I'll do some further edits to bring it up to speed. Too bad the background and Will were deleted.. doesn't look like we can get those images back easily without going back to copying from familysearch. As for his date of birth, we don't have any information on it to be precise. The gentlemen that I've been working with estimates it was around 1708, given that when he made his Will he named 2 of his grandchildren to receive land. When you add up the years it gets to approximately 1808- You had to be 18-21 to receive land (grandchildren), and also 18-21 to be married w/ children (William), and then 18-21 to be married w/ children (James). Additionally there was an old record mentioning that James married Rebecca in 1726 (unconfirmed source, but lines up with the dates). Side note- there is not record of Rebecca's maiden name, and it is assumed to be Redman. There was a "Redman MackDaniel" that was "transported" to Maryland in 1681 and there is a theory that the Redman name passed down through the generations is actually a male name, not as a response to Rebecca's maiden name. The leading theory is that James was born in America as there are a few McDaniel's noted to also be living in Frederick, Maryland, but there is the possibility that he could have been born in Scotland or Ireland. To the point of other McDaniels in Maryland, in Jame's estate it refers to a Francis McDaniel as Kinsman. There is no record of a Francis being associated to Lt. Brian McDaniel's family.
I've been working on a introduction to add to this profile and other locations to help avoid any other confusion or mis-association with Lt. Brian. I'll be posting that on the page soon and I'll also work on the profile. If anyone wants more information regarding the DNA specs, I can give them.
Thank you.