me >> Mom >> presumed GP >> brother of presumed GP [my great uncle] >> son of brother of presumed GP [the known DNA relative]
Would this be my 2C if my hypothesis is true?
NO - that is a 1C1R relationship. He is your mothers first cousin and you are 1 generation removed.
Target >> his father >> father's brother >> his child (my mother) >> me
In looking at the cousin chart, I keep ending up with the relationship of 1C1R. What am I doing wrong?
There is nothing wrong. 1C1R is the correct relationship in that situation.
What proof do you have for the second cousin relationship?
Second cousins have the same GREAT grandparents in common, not the same grandparents.