Should be fun one to solve.
Both are named Lewis Huffman, both are born with a guess year around 1785, both are born in Germany, both referenced in 2 genealogical biography books related to Western Pennsylvania/Allegheny County. Spouse identified in one, 2 different children also identified.
Update (an unsourced clue): Family search has Lewis born 1748-1862 and Jacob 1799-1865
Another unsourced tree on family search has a Lewis born 1784-1863
OK, I think I've come to the conclusion that they are different people. Looks like one has a mother Hester Beam, the other has a mother Catherine, and it looks like the 2 Lewis birth dates way off.