His father's will notes that he was unable to take care of himself.
Sources
"Rhode Island Births and Christenings, 1600-1914," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:F87N-W6R : 10 February 2018), Nicholas Hopkins in entry for Nicholas Hopkins, 30 May 1760; citing SCITUATE TWP,PROVIDENCE,RHODE ISLAND, reference ; FHL microfilm 22,256.
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DNA Connections
It may be possible to confirm family relationships with Nicholas by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: