Issac was born about 1845. He was the son of John Little and Ruth Honeycutt. He passed away about 1870.
Sources
"United States Census, 1850," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MZYC-WGC : 12 April 2016), Isaac A Little in household of John Little, Paulding county, Paulding, Georgia, United States; citing family 831, NARA microfilm publication M432 (Washington, D.C.: National Archives and Records Administration, n.d.).
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DNA Connections
It may be possible to confirm family relationships with Issac by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Issac: