"United States Census, 1910," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:M2BW-7MC : accessed 30 September 2018), Isaac S Mathis in household of Samuel F Mathis, Spring Creek, Phelps, Missouri, United States; citing enumeration district (ED) ED 72, sheet 1A, family 7, NARA microfilm publication T624 (Washington D.C.: National Archives and Records Administration, 1982), roll 797; FHL microfilm 1,374,810.
"United States Census, 1920," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MN1Q-VX8 : accessed 30 September 2018), Isaac Mathis in household of Samuel F Mathis, Turney, Texas, Oklahoma, United States; citing ED 197, sheet 6A, line 15, family 99, NARA microfilm publication T625 (Washington D.C.: National Archives and Records Administration, 1992), roll 1488; FHL microfilm 1,821,488.
"United States Census, 1930," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:XHNZ-FTS : accessed 30 September 2018), Isac S Mathis in household of Samuel F Mathis, Dillon, Phelps, Missouri, United States; citing enumeration district (ED) ED 6, sheet 4B, line 61, family 88, NARA microfilm publication T626 (Washington D.C.: National Archives and Records Administration, 2002), roll 1216; FHL microfilm 2,340,951.
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isaac: