Mary was born about 1867.
[1]
She passed away about 1944.
Sources
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"Massachusetts, Town Clerk, Vital and Town Records, 1626-2001," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/1:1:DCB1-1YPZ : 10 November 2020), Mary E. Prescott, 24 Mar 1867; citing Birth, Lowell, Middlesex, Massachusetts, United States, Massachusetts Secretary of the Commonwealth, Boston; FHL microfilm 007011248.
"United States Census, 1940," database with images, FamilySearch (https://www.familysearch.org/ark:/61903/1:1:K4VR-4LD : 10 January 2021), Minnie Sheppard, Lowell, Middlesex, Massachusetts, United States; citing enumeration district (ED) 18-37, sheet 4A, line 29, family 81, Sixteenth Census of the United States, 1940, NARA digital publication T627. Records of the Bureau of the Census, 1790 - 2007, RG 29. Washington, D.C.: National Archives and Records Administration, 2012, roll 1691.
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DNA Connections
It may be possible to confirm family relationships with Mary by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Mary: