Isaac was born in 1845. He passed away after 1890.
Sources
n.s.h.v.s year 1870 page 41 book 1812 number 104
he was 26 years old
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isaac: