I have found some record for people that are seemingly his children recorded under surnames Ashiron, Oshiron, and Ashuron.
There are two death records that seem to be his daughters:
OSHIRON, Meryam Tsyvya. Parents' names are not given. Dies 12/7/1861, 17 Av, in Vilnius. Age 4. Cause of death is consumption. The record is the first one on this image, that is image 836 out of 1001, record F285.
OSHIRON, Freyda, daughter of Leyba. Dies exactly one week after Meryam, 19/7/1861, 24 Av, in Vilnius. Age 1. Cause of death is again consumption. That record is in the middle of this image, that is image 837 out of 1001, record F295.
1834 revision list. Leyb Asiran, son of Mordukh, age 11.
1851 revision list. Leyb Aseron, son of Mordukh, age 28.
1858 revision list. Leyba Aspron, son of Mordukh, age 36.
1874 list. Leyb Anspron, son of Mordkhel, age 52. And his son Shmuel Anspron, age 8. The type of record is "Jewish Males Registered in Vilnius Gubernia and Residing in Kaunas Gubernia". Entry says "Registered In Vilnius; Resides In Gruzdziai Volost, Siauliai Uyezd". (I do not find any other records of the family in Gruzdžiai.)
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It may be possible to confirm family relationships with Leyba by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Leyba: