Lord Sidney married 9 December 1736, Mary Norris, the daughter and eventual heir of Thomas Norris, MP, of Speke Hall, Lancashire, and his wife, Magdalen Aston.  She may have been born 22 March 1698 at Speke.
Sidney was educated at Eton and Trinity College, University of Oxford, where he achieved the degrees of MA in 1727 and Doctor of Civil Law in 1733.
He was returned as MP for New Windsor in the Parliament of 1733. He was also a courtier who acquired the posts of Master of His Majesty’s Harriers and Lord of the Bedchamber to George II. He was Vice Chamberlain of His Majesty’s Household 1740–42, which gave him membership of the Privy Council.
Sidney had a home in Windsor, and in Pall Mall London. He also had access to his wife's inherited property, Speke Hall in Liverpool. 
Sidney had smallpox in November 1734.
Sidney died 23 November 1744,  and Mary died 20 November 1766.
British Newspaper Archive, Family Notices," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:QPZW-B26Z : 17 April 2019), Sidney Beauclerk, Lord, Edinburgh, Edinburghshire, Scotland, United Kingdom; records extracted FamilySearch and images digitized by FindMyPast; citing Edinburgh, Edinburghshire, Scotland, United Kingdom, 1 Nov 1744, The British Newspaper Archive, Ireland; FHL microfilm .
Noy, David. Dr Johnson’s Friend and Robert Adam’s Client Topham Beauclerk. Cambridge Scholars.com pg 2
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It may be possible to confirm family relationships with Sidney by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: