The source for Margaret's middle name of "Lydia" and her surname of "Boyd" is unknown.
Perhaps of interest is the fact that Ancestry.com's DNA test has suggested "Mary Adline Boyd" (born 1834 in Tennessee) as a possible ancestor or close relative of an ancestor of a descendant of Margaret. However, these suggestions can only be considered hints for further study and must be treated cautiously. Boyd is a common name, and this could easily be a coincidence.
Autosomal DNA segments have been triangulated through descendants of several children of Margaret. It is always possible that Margaret was not the only wife of George and that the origin of the segments are on the Wells side. Until these segments find a commonality in an earlier generation that can be ascribed to Margaret, the confirmation of a DNA connection should be handled with the usual care.
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It may be possible to confirm family relationships with Margaret by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Margaret: