George Calvert was son and heir of Leonard Calvert, by Alice, daughter of John Crossland. He was born at Kipling (in Bolton), Yorkshire, in 1578 or 1579. 
Little is known of George's origins, except that he came from Yorkshire the son of Leonard Calvert, born about 1579. It appears that George's father was a Roman Catholic, although his father was compelled by law to have George tutored by a Protestant. George matriculated (entered) Trinity College, Oxford, at the age of 14 in 1593/4, and received his bachelor's degree in 1597, having studied foreign languages. At some point, he would have had to swear allegiance to the Crown, which would have included a denial that the Pope had authority over the Church of England. After Oxford, he studied law at Lincoln's Inn in London for three years. 
He became the secretary and protege of Sir Robert Cecil, after whom he named his eldest son. 
He matriculated aged 14 at Trinity College, Oxford, in 1594, and received a BA degree in1597.
1604 Marriage to Anne Mynne
On 22 November 1604 at Hertingfordbury, Hertfordshire, George Calvert married Anne Mynne, the daughter of George Mynn, Esq, of Hertingfordbury, Hertfordshire and his wife Elizabeth Wroth. 
George, gentleman of St. Martins-in-the-Field, married, by license, Anne Mynne, of Hertfordshire, daughter of John Mynne, a Protestant, on November 22, 1604 at St. Peter's, Cornhill, London.
She died 8 August 1622, and was buried at Hertingforfdbury, Hertfordshire.
His wife Anne died in 1622 and is buried at St. Martins-in-the-Fields, a Protestant church. 
1616 Danby Lenske
In 1616 King James I granted the manor of Danby Wiske to George Calvert, who subsequently became Lord Baltimore. 
Offices and Lands
George Calvert, Knt, was of Danbywiske, Yorkshire. 
During his career he was
Under Secretary of State
Clerk of the Privy Council
Burgess (MP for Bossiney, 1605
Knight of the Shire for Yorkshire, 1609-11
Secretary of State, 1620-02
Privy Councillor, 1619-1625.
Fact: Christening (1579) Danby Wiske, Yorkshire, England
Fact: Immigrated (1606) Private sec to Sir Robert Cecil
Fact: unknown (29 SEP 1617) Knighted by King James I
Fact: Knighted (29 September 1617)
Fact: Land (BEF 1617) 2300 acres in Langfrod, Ireland-Manor of Baltimore
Fact: Religion (1624) Convert to Catholic
Fact: Occupation (1625) Retired from public life
Fact: Burial (15 April 1632) London St John the Baptist, London, England
Fact: George Calvert, 1st Baron Baltimore (29 October 2013 (the last update)) This document shows that "Brother Calvert" is a significant historical figure. You've got to see this!
Fact: baptism Great Morrshams, Parish of Skelton, Yorkshire, England
Fact: Land 2300 acres in Langfrod,Ireland-Manor of Baltimore
Fact: Children Calvert had a total of thirteen children: Cecil, who succeeded his father as the 2nd Baron Baltimore, Leonard, Anne, Mary, Dorothy, Elizabeth, Grace, Francis, George, Helen, Henry, John, and Philip
He resigned his preferments in February 1624/5, having become a Roman Catholic. 
However, as he had received large grants of land in Ireland, he was created Lord Baltimore, of Baltimore, County Longford, Ireland, 16 Feb 1624/5.
Calvert held many high offices and was very involved in the foreign affairs of the Crown, but the political atmosphere and religious intolerance became intolerable, and in 1625 Calvert resigned his position as one of two Secretaries of State. When he resigned, the King, James I, confirmed Calvert's position on the Privy Council, and George was appointed Baron Baltimore in county Longford, Ireland. He converted to Catholicism, probably in late 1624. 
The Calvert's were known for their religious tolerance, allowing Catholic refugees as well as others, to settle in Maryland. 
1627 Marriage to Joan
In or before 1627 he married Joan. They had one son
George was very involved in the colonization of the New World. He invested in the Virginia Company, then in the East India Company. He purchased land in at Ferryland on the Alvan Peninsula, Newfoundland and established a colony there called Avalon. You can read about the settlement at Ferryland, Newfoundland and about the Avalon Peninsula at Wikipedia.
After the settlement at Avalon failed in 1629 due to an unusually harsh winter, Calvert tried to get a charter to establish a new colony in a warmer climate. He was denied a colony in Virginia, but he was final granted a charter for lands in Maryland. Unfortunately, it was too late, as Calvert had died five weeks earlier. His son Cecil, 2nd Baron Baltimore, inherited his father's title and lands. Cecil's younger brother, Leonard, was the first Proprietary Governor of the Maryland. Although George Calvert, 1st Baron Baltimore, never actually set foot in Maryland, he is considered its founder.
He received a grant of Maryland from King Charles I, but never visited Maryland.
Sir George Calvert, First Lord Baltimore, died 15 April 1632, and was buried at St. Dunstan's in the West, London.
George Calvert died on April 15, 1632, at the age of 54. He is buried at St Dunstan-in-the-West Church, Fleet Street, City of London
Greater London, England.
George and Alice had six sons and five daughters:
↑ London, England, Baptisms, Marriages and Burials, 1538-1812 [Ancestry.com. database on-line]. Provo, UT, USA: Ancestry.com Operations, Inc., 2010. Original data: Church of England Parish Registers, 1538-1812. London, England: London Metropolitan Archives. Images produced by permission of the City of London Corporation Libraries, Archives. London Metropolitan Archives, St Peter Cornhill, Composite register: baptisms 1538 - 1774, marriages 1538/9 - 1754, burials 1538/9 - 1774, P69/PET1/A/001/MS08820.
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It may be possible to confirm family relationships with George by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: