Erwin Chargaff

Erwin Chargaff (1905 - 2002)

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Erwin Chargaff
Born in Czernowitz, Duchy of Bukovina, Austria-Hungarymap
Son of [father unknown] and [mother unknown]
[sibling(s) unknown]
[spouse(s) unknown]
[children unknown]
Died in New York, New York, USAmap
Profile manager: Mark Burch private message [send private message]
Profile last modified | Created 19 Nov 2017
This page has been accessed 131 times.

Categories: Austrian Notables | Chemists.

Notables
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Biography

Erwin was born in 1905. He passed away in 2002. [1] [2]

Erwin Chargaff was an Austro-Hungarian biochemist that immigrated to the United States during the Nazi era and was a professor of biochemistry at Columbia University medical school. Through careful experimentation, Chargaff discovered two rules that helped lead to the discovery of the double helix structure of DNA.

The first rule was that in double-stranded DNA the number of guanine units is equal to the number of cytosine units, and the number of adenine units is equal to the number of thymine units. This hinted at the base pair makeup of DNA. It has also been found that the melting temperature of DNA (temperature at which 50% of double strands separate) correlates with GC content, in part due to increased hydrogen bonding in G-C pairs.

The second rule was that the relative amounts of guanine, cytosine, adenine and thymine bases vary from one species to another. This hinted that DNA rather than protein could be the genetic material.

Chargaff's rules along with Rosalind Franklin's Photo 51 helped Watson and Crick devise their double-helix model of DNA.


Erwin Chargaff Married Vera Broido on 17 Sep 1929 in Manhattan, New York, New York, United States

Father's Name: Herman Chargaff

Mother's Name: Rosa Silberstein

Spouse's Birth Year: 1907 (Age 22) Birthplace: Russia

Spouse's Father's Name: Leo Mother's Name: Tomasi F. Ratner [3]

Sources

  1. https://en.wikipedia.org/wiki/Erwin_Chargaff
  2. "United States Social Security Death Index," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:JR3D-TM5 : 20 May 2014), Erwin Chargaff, 20 Jun 2002; citing U.S. Social Security Administration, Death Master File, database (Alexandria, Virginia: National Technical Information Service, ongoing).
  3. "New York, New York City Marriage Records, 1829-1940," database, FamilySearch (https://familysearch.org/ark:/61903/1:1:248S-PYC : 20 March 2015), Erwin Chargaff and Vera Broido, 17 Sep 1929; citing Marriage, Manhattan, New York, New York, United States, New York City Municipal Archives, New York; FHL microfilm 1,653,942.


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DNA
No known carriers of Erwin's ancestors' Y-chromosome or mitochondrial DNA have taken yDNA or mtDNA tests and no close relatives have taken a 23andMe, AncestryDNA, or Family Tree DNA "Family Finder" test.

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Images: 4
Erwin Chargaff
Erwin Chargaff

Heraclitean Fire by Erwin Chargaff
Heraclitean Fire by Erwin Chargaff

Chargaff's rules explained by hydrogen bonding in A-T and G-C pairs
Chargaff's rules explained by hydrogen bonding in A-T and G-C pairs

DNA melting temp. correlates with GC content
DNA melting temp. correlates with GC content

Collaboration

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