Estelle grew up in India, where her parents were serving as missionaries. She attended Wooster College in Ohio to earn her college degree. She graduated 1923. "Estelle Cyrena Clark, a Lahore, Junjab, India, born November 5, 1901. Wooster Academy. YWCA; Volunteers; Basketball; Manager; Hockey; Castalian; Oratorio; 'How doth the little busy bee improve each shining hours!'"
After graduating from college, Estelle most likely returned to India and became a missionary. At the time of her mother's death in 1948, Estelle was a nurse missionary in a Presbyterian Hospital at Ambala City, Punjab India.
Estelle died 21 November 1984 in Durate, Los Angeles, at the age of 83.