She married James McGuire about 1800 , probably in Montgomery County, Kentucky (James recorded there in 1800 and 1801). They subsequently moved into Floyd Co. and finally to Morgan Co., KY. Sarah appears to be the mother of all of James' children. Those children are thought to have been:
John Milton McGuire, 1802-1863; m. Mary Cook 8 May 1827 Morgan Co.
Rebecca McGuire, 1803-1880; married James Elam 11 September 1823 Morgan Co.
William McGuire, 1806-1863; m. Rebecca Elam 16 October 1823 Morgan Co.
Ambrose Coffee McGuire, 1810-1898; m. Nancy Jane Cook c1827; had son James C. McGuire (1838-1904), m. Elizabeth Brown 2 April 1867.
Jane McGuire, 1812-1867; m. Adale Buffington 11 July 1830 Morgan Co.
Nancy McGuire, 1814-1849; m. Ambrose Lemaster 28 May 1831 OR 9 August 1832 Morgan Co.
Elijah C. McGuire, 2 January 1816-1 May 1888 Greenup Co., KY; m. Sarah A. Nickell 10 September 1836 Morgan Co. She lived c1820-1 July 1888 Greenup Co., KY.
Ailsey McGuire, 1819-1880; m. Fielding B. Cook 1 January 1844 Morgan Co.
Samuel W. McGuire, 1822-1891; m. Frances A. May 1 April 1848 Morgan Co.; married second Priscilla Nickell 13 May 1876.
Jesse I./J. McGuire, 1824-1913; m. Margaret A. P. May 5 October 1844 Morgan Co.
Others?
After Sarah died, James remarried twice (see his profile for details).
Sources
1810 Federal Census, Floyd County, Kentucky; James McQuire, 3 males <10, 1 male 26-44, 1 female <10, 1 female 26-44.
1820 Federal Census, Floyd County, Kentucky; James McGuire (#1), 1 male <10, 2 males 10-15, 1 male 16-25, 1 male 26-44, 3 females <10, 1 female 16-25, 1 female 26-44.
1830 Federal Census, Morgan County, Kentucky; Capt. James McGuire, 2 males 5-9, 1 male 10-14, 1 male 15-19, 1 male 20-29, 1 male 50-59, 1 male 70-79, 1 female 5-9, 2 females 10-14, 1 female 30-39, 1 female 70-79. Note: The man and woman aged 70-79 were probably John McGuire born 1756 and wife Nancy.
Notes as to Sarah Coffee thought to have married James McGuire s/o John the RW Pensioner b 1756 - ]The papers of Mrs. Dayton Royse, (Elmyra McGuire) of Oklahoma City, were donated to the Genealogical Library of Oklahoma by her son after her death. They are currently accessible at the Research Center of the Oklahoma Historical Society. The contents of the collection can be seen through their website: http://www.okhistory.org/
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DNA Connections
It may be possible to confirm family relationships with Sarah by comparing test results with other carriers of her mitochondrial DNA.
Mitochondrial DNA test-takers in the direct maternal line: