"United States Census, 1880," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:MCC3-YQ5 : 11 August 2016), Isaac Combs in household of Henry Combs, Troublesome, Breathitt, Kentucky, United States; citing enumeration district ED 16, sheet 640B, NARA microfilm publication T9 (Washington D.C.: National Archives and Records Administration, n.d.), roll 0405; FHL microfilm 1,254,405.
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
Y-chromosome DNA test-takers in his direct paternal line on WikiTree: