The very first First Lady of VA. Daughter of Nathaniel West Dandridge b. 07 Sep 1729 and Dorothea Spotswood b. 1733. Cousin of Martha Dandridge Washington, wife of George Washington.
In her obituary, DOROTHEA SPOTSWOOD DANDRIDGE HENRY WINSTON was acclaimed to be “of the ancient Dandridge family.” Yes, she was of this “ancient family,” but more than that, she lived in one of the most important eras of United States history and was “up to the task” as the expression goes!
Dorothea “Dolly” was born, 25 September 1757 , to Nathaniel West Dandridge (b 7 Sept 1729) and his wife, Dorothea Spotswood (b1733) in Hanover County, Virginia, and the grand-daughter of colonial Virginia Governor Alexander Spotswood (c. 1676 – 6 June 1740). Dandridge Spending her early life on a thriving plantation, she had frequent contact with “movers and shakers” of the growing rebellion against English tyranny. Indeed, she and George Washington’s wife, Martha Dandridge Custis were cousins.
On 09 Oct 1777, soon after her twentieth birthday, she married Patrick Henry, whose first wife had died in 1775. After he was elected to his second term as first governor of the newly independent commonwealth of Virginia, Young Dorothea Spotswood Dandridge Henry played her role as the first FIRST LADY of the Commonwealth of Virginia with tact and grace. Also, she took over the role of mother of the children by Henry's first marriage, some of whom were almost as old as she. Dorothea appears to have been accepted and well-liked as a stepmother. She and Henry had eleven children together:
Sarah Butler b. 1780 who married Alexander Scott;
Martha Catherina b. 1781 who married Edward Henry;
Patrick Jr. b. 1783 who married Elvira Cabell;
Fayette b. 1785 who married Anne Elcan;
Alexander Spotswood b. 1788 who married Pauline Cabell;
Dorothea Spotswood b. 1788 who married George Winston;
Nathaniel West b. 1790 who married Virginia Woodson;
Richard b. 1792 d. 1793;
Edward Winston b. 1794 who married Jane Yuille;
John b. 1796 who married Elvira McClelland (both buried at this cem.); and
Jane Robertson Henry b. 1798 d. 1798 (buried at this cem).
Henry had already purchased Leatherwood plantation, where he grew tobacco and practiced law in what was to become Henry County. After completing his second term as governor in 1779 he and Dorothea moved there. 
Red Hill plantation
In 1794, they retired to Red Hill Plantation, comprising 520 acres (2.1 km2) in Charlotte County, which was also a functioning tobacco plantation.
After Patrick Henry's death (6 June 1799), twenty-two years after they were married, Dorothea, with 17 children (6 from Patrick's first marriage to Sarah Shelton), married Judge Edmund Winston who was Patrick Henry's executor and first cousin; they lived in "Huntingtour" in Nelson County, Virginia. She may have married the executor since Patrick Henry's will stated that if Dorothea remarried, all the land and slaves would be inherited by his surviving children.
She died 14 Feb 1831 at age 73 at “Seven Islands” in Halifax County, Virginia. Because of inclement weather, she was initially buried at “Seven Islands”; she was subsequently re-interred at “Red Hill” beside Patrick Henry, in Henry Cemetery. 
It may be possible to confirm family relationships with Dorothea by comparing test results with other carriers of her mitochondrial DNA.
However, there are no known mtDNA test-takers in her direct maternal line.
It is likely that these autosomal DNA test-takers will share DNA with Dorothea: