Isabella of Bourbon (1436 ? September 25, 1465) was the second wife of Charles the Bold, Count of Charolais and future Duke of Burgundy. She was a daughter of Charles I, Duke of Bourbon and Agnes of Burgundy, and the mother of Mary of Burgundy (1457 ? 1482).
She and the Count of Charolais married in 1454, and their marriage was reportedly good, perhaps due to her husband's faithfulness.
In 1459, Isabella stood godmother to Joachim, the short-lived son of the refugee Dauphin of France and his second wife, Charlotte of Savoy. Upon his succession to the throne of France, the Dauphin abandoned his wife in Burgundy, leaving the young Queen Charlotte dependent on Isabella's aid.