Isaac was born in 1765. He was the son of Thomas Drake and Mary Manley. He passed away in 1830.
FSFTID KCQX-B1G.
Sources
"Massachusetts, Town Clerk, Vital and Town Records, 1626-2001," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:Q29G-59ZY : 5 November 2017), Isaac Drake, 27 Mar 1765; citing Birth, Easton, Bristol, Massachusetts, United States, , town clerk offices, Massachusetts; FHL microfilm 1,059,951.
"Vermont Vital Records, 1760-1954," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:XFV7-BJP : 3 November 2017), Isaac Drake, 15 Mar 1830, Death; State Capitol Building, Montpelier; FHL microfilm 27,534.
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his ancestors' Y-chromosome or mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isaac: