William Dryden was the youngest son of Sir Erasmus Dryden, 1st Bt. and Frances Wilkes.
He married (unknown) Cave. They had one son John Dryden, who succeeded to the baronetcy Dryden after the death of his cousin, the 3rd Baronet.
He died circa December 1660. He was buried on 24 December 1660. He lived at Farndon, Northamptonshire, England
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