"North Carolina, County Marriages, 1762-1979 ," database with images, FamilySearch (https://familysearch.org/ark:/61903/1:1:Q2R1-VGR5 : 3 February 2017), Margaret M. Knox and MM9.1.1/Q2R1-VGRY:, 1783; citing North Carolina, United States, p. , Office of Archives and History, Division of Archives and Records. State Archive of North Carolina and various county Register of Deeds; FHL microfilm 422,158
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DNA Connections
It may be possible to confirm family relationships with Isaac by comparing test results with other carriers of his Y-chromosome or his mother's mitochondrial DNA.
However, there are no known yDNA or mtDNA test-takers in his direct paternal or maternal line.
It is likely that these autosomal DNA test-takers will share some percentage of DNA with Isaac: